Approach to acute renal failure in biopsy proven myeloma cast nephropathy: is there still a role for plasmapheresis?
نویسندگان
چکیده
myeloma cast nephropathy: Is there still a role for plasmapheresis? Luana Pillon, Raeshell S. Sweeting, Avi Arora, Alicia Notkin, Harold S. Ballard, Rosemary L. Wieczorek and Nelson Leung Department of Medicine, VA New York Harbor Health Care Systems, New York, New York, USA; Department of Medicine, New York University School of Medicine, New York, New York, USA; Division of Nephrology, Department of Medicine, New York University School of Medicine, New York, USA; Division of Hematology, Department of Medicine, New York University School of Medicine, New York, USA; Division of Pathology, Department of Medicine, New York University School of Medicine, New York, USA and Mayo Clinic, Division of Nephrology and Hypertension, Department of Medicine, Rochester, Minnesota, USA
منابع مشابه
Markers of bone turnover in haemodialysis patients.
patients with myeloma is likely to be increased because myeloma-associated with a bleeding diathesis (as the authors note). Indeed, the largest and most recent trial of plasmapheresis for myeloma-associated kidney failure did not specify kidney biopsy as an inclusion criterion because of concerns about the risks vs benefits of the procedure [2]. Can the authors specify how a biopsy result will—...
متن کاملHigh cut-off dialyser haemodialysis in cast nephropathy
Sir, The importance of renal function in the prognosis of patients with multiple myeloma (MM) has been well established and rapid reversal of renal failure may offer the best long-term outcome. The use of extracorporeal means of removing immunoglobulin free light chains (FLCs) responsible for cast nephropathy in patients with MM is controversial. Nephrologists are interested in a treatment stra...
متن کاملResolution of cast nephropathy following free light chain removal by haemodialysis in a patient with multiple myeloma: a case report
INTRODUCTION Acute renal failure in multiple myeloma is most frequently caused by cast nephropathy, when excess monoclonal free light chains co-precipitate with Tamm-Horsfall protein in the distal nephron, causing tubular obstruction. The natural history of cast nephropathy after diagnosis is unknown. This report provides supporting histological evidence that, as serum free light chain concentr...
متن کاملCast nephropathy in multiple myeloma.
Case report A 54-year-old man presented with one-week history of bilateral loin pain, reduced urine output and malaise. Complete blood picture showed hemoglobin of 7.6g/dL (normal: 11.5-17g/dL) Serum biochemistry showed hypercalcemia and markedly impaired renal function with creatinine measuring 1081 µmol/L (normal: 80-120). Skeletal survey showed multiple osteolytic lesions, and bone marrow as...
متن کاملLambda light chain myeloma with oliguric cast nephropathy and remission with bortezomib, doxorubicin and dexamethasone.
Cast nephropathy is one of the major causes of renal failure in patients with multiple myeloma resulting from precipitation of free light chains inside the tubules. Timely diagnosis and treatment confers a better prognosis though around 10% of patients with cast nephropathy remain dialysis dependent in spite of treatment. We report the clinical course and outcome of a patient presenting with ac...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Kidney international
دوره 74 7 شماره
صفحات -
تاریخ انتشار 2008